COTRCollaborative Orthopedic Trauma Research Group
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Research

Research lane 03

AI & Imaging

Machine-learning and generative-AI studies in orthopaedics, from fracture and meniscus detection on radiographs, CT, and MRI to models that predict complications after surgery. We also test how accurate and readable chatbot answers to patient questions are.

Detection locks onto a distal radius fracture (AO/OTA 23-A2). Illustrative.
Publications
7
Presentations
13

Guiding questions

What this lane asks

  1. Detection

    Can a model find and classify fractures and meniscus tears on radiographs, CT, or MRI?

  2. Prediction

    Can routinely collected data predict who will have a complication after surgery?

  3. Patient answers

    How accurate and readable are chatbot answers to a real patient question?

Selected work

Key publications

Journal Article

Meta-analysis and Systematic Review of Diagnostic Performance of Machine Learning Algorithms on Skeletally Mature Wrist Fractures

Reem Sarsour, Sultan Baz, Christopher E. Collins, Angelene Won, Peter Aldo Giammanco, James Hagerty, and 3 more, Joseph G. Elsissy

Show all 10 authors

Reem Sarsour, Sultan Baz, Christopher E. Collins, Angelene Won, Peter Aldo Giammanco, James Hagerty, Jose Jesurajan, Brian A. Schneiderman, Evelyn Ouro-Rodrigues, Joseph G. Elsissy

HAND

Wrist fractures are prevalent, and the diagnostic performance of artificial intelligence for their detection requires clarification. This study aims to determine the diagnostic accuracy of machine learning in detection of scaphoid fractures, distal radius fractures, and other types of wrist fractures on skeletally mature wrist radiographs through a meta-analysis while accounting for heterogeneity of studies using a random-effects model. In addition, this study will compare the results of machine learning to those of experts, including orthopedic surgeons, hand surgeons, and radiologists.

Journal Article

Diagnostic Accuracy of Artificial Intelligence for Detection of Meniscus Pathology on Magnetic Resonance Imaging: A Systematic Review

Peter A Giammanco, Christopher E Collins, Sunny M Trivedi, Reem O Sarsour, Mikayla Kricfalusi, Joseph G Elsissy

Cureus

Meniscus tears can be difficult to diagnose on magnetic resonance imaging (MRI) due to the various types of tears. As artificial intelligence (AI) continues to advance, it could serve as a valuable tool that assists physicians with diagnostic accuracy and efficiency. The purpose of this study was to analyze the performance of AI in diagnosing meniscus tears on MRI using an array of studies and to compare the performance of AI to that of physicians. A literature search was conducted on PubMed and Embase for articles regarding the use of AI for the detection of meniscus tears. AI model, number of MRI studies, sensitivity, specificity, accuracy, AUC, and comparison to physicians encompassed the data that was extracted. A total of 18 studies, comprising 47,621 MRIs, were included in this review. The AUC of these AI models ranged from 0.781 to 0.984, averaging 0.912±0.053. The pooled sensitivity and specificity were 0.831±0.097 and 0.868±0.088, respectively. Three of these studies compared their results to those of 10 radiologists and two orthopedic surgeons. When comparing the sensitivity and specificity of AI models to those of physicians, Cochrane's Q was statistically significant (p < 0.01) with large heterogeneity amongst the two groups (I2 = 84.72%). The results suggest that AI's ability to detect meniscus lesions on MRI was relatively strong. When this performance was compared to that of physicians, the results were comparable, highlighting the potential benefits in a clinical setting.

Credited on this lane

Investigators & contributors

Publications

2026, 2 publications

Journal Article

Meta-analysis and Systematic Review of Diagnostic Performance of Machine Learning Algorithms on Skeletally Mature Wrist Fractures

Reem Sarsour, Sultan Baz, Christopher E. Collins, Angelene Won, Peter Aldo Giammanco, James Hagerty, and 3 more, Joseph G. Elsissy

Show all 10 authors

Reem Sarsour, Sultan Baz, Christopher E. Collins, Angelene Won, Peter Aldo Giammanco, James Hagerty, Jose Jesurajan, Brian A. Schneiderman, Evelyn Ouro-Rodrigues, Joseph G. Elsissy

HAND

Also in AI & Imaging

2025, 3 publications

Journal Article

Evaluating the Quality and Readability of Generative Artificial Intelligence (AI) Chatbot Responses in the Management of Achilles Tendon Rupture

Christopher E Collins, Peter A Giammanco, Monica Guirgus, Mikayla Kricfalusi, Richard C Rice, Rusheel Nayak, and 2 more, Joseph G Elsissy

Show all 9 authors

Christopher E Collins, Peter A Giammanco, Monica Guirgus, Mikayla Kricfalusi, Richard C Rice, Rusheel Nayak, David Ruckle, Ryan Filler, Joseph G Elsissy

Cureus

Also in AI & Imaging

Show 2 more publications

2025, 1 publication

Journal Article

Evaluating the Quality and Readability of Information Provided by Generative Artificial Intelligence Chatbots on Clavicle Fracture Treatment Options

Peter A Giammanco, Christopher E Collins, Jason Zimmerman, Mikayla Kricfalusi, Richard C Rice, Michael Trumbo, and 3 more, Joseph G Elsissy

Show all 10 authors

Peter A Giammanco, Christopher E Collins, Jason Zimmerman, Mikayla Kricfalusi, Richard C Rice, Michael Trumbo, Bradley A Carlson, Rebecca A Rajfer, Brian A Schneiderman, Joseph G Elsissy

Cureus

Also in AI & Imaging

2024, 1 publication

Open in the publications library

Presentations

Poster presentation · 2025

Evaluating Quality and Readability of Information Provided by Generative Artificial Intelligence Chatbots on Clavicle Fracture Treatment Options

Dr. Joseph Elsissy

OtherCarmel, CA

Poster presentation · 2025

Meta-Analysis and Systematic Review of Diagnostic Performance of Machine Learning Algorithms on Adult Wrist Fractures

Dr. Joseph Elsissy

OtherColton, CA

Poster presentation · 2024

A Comparison of Convolutional Neural Networks Versus Orthopedic Physicians in Diagnosing Knee Osteoarthritis Severity

Dr. Joseph Elsissy

AAOSSan Francisco, CA

Show 10 more

Podium presentation · 2024

Assessing Quality and Readability of AI Responses on Patellar Tendon Repair

Richard "Casey" Rice, Rusheel Nayak, Tate Cowley, Matthew Gulbrandsen, Dr. Joseph Elsissy, Monica Guris

OtherTampa, FL

Podium presentation · 2024

Comparing Diagnostic Metrics of Osteoarthritis Severity between AI Neural Networks and Orthopaedic Physicians

Dr. Joseph Elsissy

OtherLoma Linda, CA

Poster presentation · 2024

Comparing Diagnostic Metrics of Osteoarthritis Severity Between AI Neural Networks and Orthopedic Physicians

Dr. Joseph Elsissy

OtherLoma Linda, CA

Poster presentation · 2024

Evaluating AI Language Model Quality of Information Regarding Achilles Rupture

Dr. Joseph Elsissy

OtherLas Vegas, NV

Poster presentation · 2024

Evaluating Quality and Readability of Information Provided by Generative Artificial Intelligence Chatbots on Clavicle Fracture Treatment Options

Dr. Joseph Elsissy

OtherLas Vegas, NV

Podium presentation · 2024

Evaluating the Quality and Readability of Generative AI Chatbots Responses in the Management of Achilles Tendon Rupture

Dr. Joseph Elsissy

OtherTampa, FL

Podium presentation · 2024

Machine Learning Algorithms Predict Deleterious Outcomes after Elective Trimalleolar ORIF

Dr. Joseph Elsissy

OtherLoma Linda, CA

Poster presentation · Podium presentation · 2024

Machine Learning Predicts Complications Following Cephalomedullary Osteosynthesis of Intertrochanteric Fractures

Dr. Joseph Elsissy

OtherColton, CA

Podium presentation · 2024

The Diagnostic Accuracy of Machine Learning on Adult Wrist Radiographs

Reem Sarsour, Sultan Baz, Won, Dr. Joseph Elsissy

OtherTampa, FL

Poster presentation · 2024

The Role of AI in Patient Education: Assessing Quality and Readability of Responses on Patella Tendon Repair

Dr. Joseph Elsissy

OtherTampa, FL

All presentations

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